Endocrine Abstracts

Gonarthrosis is a severe problem of movement system. It is a restrictive health problem for modern human. And also; it is the other restrictive problem which coexistence of diabetes mellitus (DM) and gonarthrosis. Perhaps; an other parameter that is deserved to research for this coexistence is metabolic syndrome. Today, relationship between this clinical conditions are clear enough. And also two lobotuary parameters as Leptin and Nesfatin-1 are an other headstone for obesity a...

Osteoarthritis is a great public health problem indiscriminately; ie goanrthritis, coxarthritis or dejenerative spine diseases. Osteoarthritis is focude sixth decades in elderly people, espicially in women. Many studies assingned the efficiancy of Diabetes Mellitus in the etiology of Osteoarthritis. Correlations between bone-destructive characteristics and carbohydrate metabolism errors is now quite accused in this clinical views. A comparing between Diabetes Mellitus Type 1 a...

Diaserein is used in the spesific and long-term treatment of degenerative joint diseases (as osteoarthritis). In vitro studies have showed that Diaserein and its active metabolyte Rheinin inhibate production and activity of interleukin-113 (IL-113), some proinflamatuar and pro-catabolic cytokines. Interleukin-113 play important role to trigger production of more pro-inflamatuar factors as cytokines, cyclo-oxygeneas, prostogalandines, nitric oxide, matrix metalloprotei...

DHEA and its sulphate derivative DHEA-sulphate (DHEA-s) are major androgen hormones of adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s levels are a useful marker in the diagnosis of hypogonadotropic hypogonadism. 91 subjects, 31 male patients diagnosed with IHH (mean age 19.7±2.6 years) and 60 healthy males (mean age 20.7±2.6 years) as a con...

Introduction: In rheumatological diseases have been observed in a rate of 0.8% of non-traumatic insufficiency fractures. The most common sites of insufficiency fractures are pelvis, sacrum, tibia, the sections near to the insertion of the fibula, calcaneus and buttocks. Generally, bone – joint involvement in rheumatic diseases and osteoporosis connected with prolonged use of corticosteroids prepares the ground for these insuffiency fractures. In this case, We aimed to pre...

Introduction: Sodium/glucose co-transporter 2 (SGLT2) inhibitors are a relatively new group of antihyperglycaemic medications for type 2 diabetes mellitus (T2DM). Euglycemic diabetic ketoacidosis (EDKA) and Fournier’s gangrene (FG) are uncommon advers effects of SGLT2 inhibitors. We report a case of a 52-year-old man who developed FG and EDKA after starting the SGLT2 inhibitor empagliflozin.Case Presentation: A-52 years old male patient attended to ...

Introduction: Sodium/glucose co-transporter 2 (SGLT2) inhibitors are novel oral hypoglycemic agents that are increasingly used in the management of type 2 diabetes mellitus (T2DM). They are now recommended as second-line pharmacotherapy (in conjunction with metformin) in patients with type 2 diabetes and established atherosclerotic heart disease, heart failure or chronic kidney disease due to their favourable effects on cardiovascular and renal outcomes. We report a case of a ...

Familial hypocalciuric hypercalcemia is an inherited disease caused by inactivating heterozygous mutations in the gene encoding calcium-sensitive receptors, that affects calcium metabolism and generally follows a benign course. It must be also considered in the differential diagnosis of hyperparathyroidism. Six patients presenting to our internal diseases clinic between January, 2010, and June, 2015, were evaluated in terms of clinical and biochemical parameters. The youngest ...

Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder characterised by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. Insulin resistance (IR) is defined as an impaired biologic response to both endogenous and exogenous insulin. IR is a common precursor to the development of glucose intolerance, including diabetes, hypertension, and cardiovascular disease. Dyslipidaemia, apol...

Introduction: Insulin antibodies, developed in patients treated with exogenous insulin, might affect glycemic control due to their tendency to bind and/or release insulin in an unpredictable fashion. It is reported to be caused by immunoglobulin G-derived insulin antibodies. Insulin antibodies induced by exogenous insulin in diabetic patients is associated with hypersensitivity reactions, glycemic variability mainly with insulin resistance/ hyperglycemia or hypoglycemia. We re...